期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 39, 期 -, 页码 21-28出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2016.05.026
关键词
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资金
- Sars International Centre for Marine Molecular Biology, University of Bergen
- Research School of Biology, Australian National University
The emergence of complex animal life forms remains poorly understood despite substantial interest and research in this area. To be informative, the ideal models to study transitions from single-cell organisms to the first animals and then to mammalian-level complexity should be phylogenetically strategically placed and retain ancestral characters. Sponges (Porifera) are likely to be the earliest branching animal phylum. When analysed from morphological, genomic and developmental perspectives, sponges appear to combine features of single-cell eukaryotic organisms and the complex multicellular animals (Eumetazoa). Intriguingly, homologues of components of the eumetazoan regulatory networks specifying the endoderm, the germ-cells and stem cells and (neuro) sensory cells are expressed in sponge choanocytes, archaeocytes and larval sensory cells. Studies using sponges as model systems are already bringing insights into animal evolution, and have opened avenues to further research benefitting from the recent spectacular expansion of genomic technologies.
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