期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 39, 期 -, 页码 168-174出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2016.07.007
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资金
- N.S.F. [IOS-1146782]
Ilyanassa obsoleta has been a model system for experimental embryology for over a century. Here we highlight new insight into early cell lineage specification in Ilyanassa. As in all molluscs and other spiralians, stereotyped cleavage patterns establish a homunculus of regional founder cells. Ongoing studies are beginning to dissect mechanisms of asymmetric cell division that specify these cells' fates. This is only part of the story: overlaid on intrinsic cell identities is a graded 'organizer' signal, and emerging evidence suggests wider roles for short-range intercellular signaling. Modern methods, combined with the intrinsic experimental advantages of Ilyanassa, offer attractive opportunities for studying basic developmental cell biology as well as its evolution over a wide range of phylogenetic scales.
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