期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 36, 期 -, 页码 8-15出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2016.01.003
关键词
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资金
- European Research Council (ERC)
- Worldwide Cancer Research Foundation
- Foundation La Marato
- Spanish Ministry of Economy and Development
- Foundation Vencer el Cancer ('Beat Cancer')
- Government of Cataluna
- Foundation Botin
- Institute for Research in Biomedicine (IRB-Barcelona)
- COFUND Marie Curie EU Action Fellowship
- ICREA Funding Source: Custom
Cancer stem cells (CSCs) have been identified in various tumours and are defined by their potential to initiate tumours upon transplantation, self-renew and reconstitute tumour heterogeneity. Modifications of the epigenome can favour tumour initiation by affecting genome integrity, DNA repair and tumour cell plasticity. Importantly, an in-depth understanding of the epigenomic alterations underlying neoplastic transformation may open new avenues for chromatin-targeted cancer treatment, as these epigenetic changes could be inherently more amenable to inhibition and reversal than hardwired genomic alterations. Here we discuss how CSC function is affected by chromatin state and epigenomic instability.
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