期刊
ANDROLOGY
卷 9, 期 1, 页码 80-87出版社
WILEY
DOI: 10.1111/andr.12907
关键词
coronavirus; fertility; male; SARS-CoV-2; testis
类别
资金
- China Postdoctoral Science Foundation [2019M661521]
The novel coronavirus outbreak in Wuhan at the end of December 2019 has threatened global health, potentially damaging male fertility; the harm may arise from viral replication and immunopathology.
In lately December 2019, a novel coronavirus (SARS-CoV-2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS-CoV-2 infection, termed COVID-19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges, reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testis; and (ii) indirect damage to male fertility derived from immunopathology. In this review, we briefly describe the impaired fertility of humans and animals infected with coronaviruses to deduce the impact of the new coronavirus on male fertility. Together with information related to other coronaviruses, we extrapolate this knowledge to the new coronavirus SARS-CoV-2, which may have a significant impact on our understanding of the pathophysiology of this new virus.
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