期刊
CURRENT OPINION IN GASTROENTEROLOGY
卷 32, 期 4, 页码 332-337出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0000000000000273
关键词
gastroesophageal reflux; intrasphincteric reflux; short-segment reflux; trans-sphincteric reflux
资金
- Clinical and Biochemical Committee of the Scottish Home and Health Department
- Chief Scientist Office [CZB/4/709] Funding Source: researchfish
Purpose of review The traditional gold standard for measuring gastroesophageal acid reflux has been by placing a pH sensor 5 cm proximal to the lower esophageal sphincter. It is known that damage induced by reflux is maximal near to the gastroesophageal junction and this has stimulated interest in determining acid reflux at that site. Recent findings The extent of esophageal exposure from refluxing gastric acid is inversely related to the distance proximal to the gastroesophageal junction. In addition, the pH transition point from gastric to esophageal pH can be displaced proximally within the lower esophageal sphincter without complete loss of sphincter tone. This intrasphincteric reflux is associated with proximal extension of cardia mucosa because of columnar metaplasia of the most distal esophageal squamous mucosa. Summary The most distal esophageal mucosa is exposed to substantially greater gastric acid refluxate than that recorded at the traditional site 5cm proximal to the lower esophageal sphincter.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据