期刊
TRANSLATIONAL STROKE RESEARCH
卷 12, 期 2, 页码 275-283出版社
SPRINGER
DOI: 10.1007/s12975-020-00845-6
关键词
Neurological deterioration; Intracerebral hemorrhage; Tranexamic acid; Randomized controlled trial; Stroke; Hematoma expansion
资金
- NIHR-HTA Programme
- Swiss Heart Foundation
The study analyzed data from the TICH-2 trial to investigate predictors and effects of neurological deterioration following intracerebral hemorrhage. Tranexamic acid was found to reduce the risk of early neurological deterioration, but had no effect on late deterioration. Larger hematoma size, intraventricular and subarachnoid extension were identified as risk factors for neurological deterioration.
Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of >= 4 or a decline in Glasgow Coma Scale of >= 2. Neurological deterioration was considered to be early if it started <= 48 h and late if commenced between 48 h and 7 days after onset. Logistic regression was used to identify predictors and effects of neurological deterioration and the effect of tranexamic acid on neurological deterioration. Of 2325 patients, 735 (31.7%) had neurological deterioration: 590 (80.3%) occurred early and 145 (19.7%) late. Predictors of early neurological deterioration included recruitment from the UK, previous ICH, higher admission systolic blood pressure, higher NIHSS, shorter onset-to-CT time, larger baseline hematoma, intraventricular hemorrhage, subarachnoid extension and antiplatelet therapy. Older age, male sex, higher NIHSS, previous ICH and larger baseline hematoma predicted late neurological deterioration. Neurological deterioration was independently associated with a modified Rankin Scale of > 3 (aOR 4.98, 3.70-6.70;p < 0.001). Tranexamic acid reduced the risk of early (aOR 0.79, 0.63-0.99;p = 0.041) but not late neurological deterioration (aOR 0.76, 0.52-1.11;p = 0.15). Larger hematoma size, intraventricular and subarachnoid extension increased the risk of neurological deterioration. Neurological deterioration increased the risk of death and dependency at day 90. Tranexamic acid reduced the risk of early neurological deterioration and warrants further investigation in ICH. URL:Unique identifier: ISRCTN93732214
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