期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 31, 期 -, 页码 126-135出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.02.017
关键词
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资金
- Biotechnological and Biological Sciences Research Council [BB/M024458/1]
- Royal Society Dorothy Hodgkin Research Fellowship
- BBSRC [BB/M024458/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M024458/1] Funding Source: researchfish
Non-heme iron-dependent oxygenases catalyse the incorporation of 02 into a wide range of biological molecules and use diverse strategies to activate their substrates. Recent kinetic studies, including in crystallo, have provided experimental support for some of the intermediates used by different subclasses of this enzyme family. Plant non-heme iron-dependent oxygenases have diverse and important biological roles, including in growth signalling, stress responses and secondary metabolism. Recently identified roles include in strigolactone biosynthesis, O-demethylation in morphine biosynthesis and regulating the stability of hypoxia-responsive transcriptibn factors. We discuss current structural and mechanistic understanding of plant non-heme iron oxygenases, and how their chemical/genetic manipulation could have agricultural benefit, for example, for improved yield, stress tolerance or herbicide development.
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