期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 33, 期 -, 页码 135-141出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.06.004
关键词
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资金
- University Cancer Research Fund
- National Institute of General Medical Sciences, US National Institutes of Health [RC1GM090732, R01GM100919]
- Carolina Partnership
The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysine reader domains with a focus on recent progress targeting chromodomains.
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