期刊
CURRENT OPINION IN CELL BIOLOGY
卷 41, 期 -, 页码 125-131出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.05.001
关键词
-
类别
资金
- NIH [NS085993, NS063228]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek ZonMw [40-00812-98-10058]
The nuclear envelope (NE) physically separates the cytoplasmic and nuclear compartments. While this barrier provides advantages, it also presents a challenge for the nuclear export of large ribonucleoprotein (RNP) complexes. Decades-old dogma holds that all such border-crossing is via the nuclear pore complex (NPC). However, the diameter of the NPC central channel limits the passage of large cargos. Here, we review evidence that such large RNPs employ an endogenous NE-budding pathway, previously thought to be exclusive to the nuclear egress of Herpes viruses. We discuss this and other models proposed, the likelihood that this pathway is conserved, and the consequences of disrupting NE-budding for synapse development, localized translation of synaptic mRNAs, and laminopathies inducing accelerated aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据