4.4 Article

Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N

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Summary: VPS35 plays a crucial role in tau metabolism and neuropathology, with its overexpression reducing pathological tau in neuronal cells while genetic silencing leads to accumulation. The availability of active cathepsin D mediates the effect of VPS35 on pathological tau accumulation, making it a potential therapeutic target for human tauopathies.

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