期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 39, 期 -, 页码 182-191出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.03.019
关键词
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资金
- National Science Foundation Graduate Research Fellowship Program [DGE-1144153]
- New Innovator Award through National Institute of General Medical Sciences of the National Institutes of Health [1DP2GM110838]
RNAs assume sophisticated structures that are active in myriad cellular processes. In this review, we highlight newly identified ribozymes, riboswitches, and small RNAs, some of which control the function of cellular metabolic and gene expression networks. We then examine recent developments in genome-wide RNA structure probing technologies that are yielding new insights into the structural landscape of the transcriptome. Finally, we discuss how these RNA 'structomic' methods can address emerging questions in RNA systems biology, from the mechanisms behind long non-coding RNAs to new bases for human diseases.
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