期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 42, 期 -, 页码 189-197出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.07.005
关键词
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资金
- NIH [R37 AI52188, R01 CA203257, R24 OD21479]
- National Center for Advancing Translational Sciences [UL1TR000117]
- University of Kentucky College of Pharmacy
- University of Kentucky Markey Cancer Center
S-Adenosyl-L-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-L-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification ('alkylrandomization').
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