期刊
CELL REPORTS
卷 32, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.108085
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类别
资金
- NIH [R01 AI121546]
- [HSV-1 gB 498-505 SSIEFARL]
CD8(+) tissue-resident memory T cells (T-RM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8(+) T-RM expressing the alpha 1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-beta and IL-12 induce CD49a expression by CD8(+ )T cells in vitro. Despite this rapid expression, CD49a is not required for the generation of a primary CD8(+) T cell response to cutaneous herpes simplex virus (HSV) infection, migration of CD8(+) T cells across the epidermal basement membrane, or positioning of T-RM within basal epidermis. Rather, CD49a supports CD8(+) T-RM persistence within skin, regulates epidermal CD8(+) T-RM dendritic extensions, and increases the frequency of IFN-gamma(+) CD8(+) T-RM following local antigen challenge. Our results suggest that CD49a promotes optimal cutaneous CD8(+) T-RM-mediated immunity.
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