期刊
CELL REPORTS
卷 33, 期 2, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.108238
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资金
- Belgium National Scientific Research Fund (FRS-FNRS)
- UCLouvain (Action de Recherche Concertee) [ARC18-23/092]
- FRS-FNRS [PINT-MULTI R.8013.19, PDR T.0068.19]
- Funds Baillet Latour (Grant for Medical Research 2015)
- FRFS-WELBIO [WELBIO-CR2017C-02]
- Fonds de Recherche Clinique of Secteur Sante de l'UCLouvain
- Wallonia (FiberTAG project from the European Joint Programming Initiative A Healthy Diet for a Healthy Life'')
- European Regional Development Fund
- Walloon Region, Belgium
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions and behavior but convincing evidence of its role in AUD is lacking. Here, we show that gut dysbiosis is associated with metabolic alterations that affect behavioral (depression, sociability) and neurobiological (myelination, neurotransmission, inflammation) processes involved in alcohol addiction. By transplanting the gut microbiota from AUD patients to mice, we point out that the production of ethanol by specific bacterial genera and the reduction of lipolysis are associated with a lower hepatic synthesis of beta-hydroxybutyrate (BHB), which thereby prevents the neuroprotective effect of BHB. We confirm these results in detoxified AUD patients, in which we observe a persisting ethanol production in the feces as well as correlations among low plasma BHB levels and social impairments, depression, or brain white matter alterations.
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