期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 22, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202001327
关键词
clinical translation; cyanine conjugates; multimodal imaging; targeted fluorescence imaging
资金
- National Key Research and Development Program of China [2016YFA0201400]
- State Key Program of National Natural Science of China [81930047]
- Projects of International Cooperation and Exchanges NSFC-PSF [31961143003]
- National Project for Research and Development of Major Scientific Instruments [81727803]
- Beijing Natural Science Foundation, Haidian, Original Innovation Joint Fund [17L20170]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]
Cyanine is a class of fluorescent dye with meritorious fluorescence properties and has motivated numerous researchers to explore its imaging capabilities by miscellaneous structural modification and functionalization strategies. The covalent conjugation with other functional molecules represents a distinctive design strategy and has shown immense potential in both basic and clinical research. This review article summarizes recent achievements in cyanine conjugate-based probes for biomedical imaging. Particular attention is paid to the conjugation with targeting warheads and other contrast agents for targeted fluorescence imaging and multimodal imaging, respectively. Additionally, their clinical potential in cancer diagnostics is highlighted and some concurrent impediments for clinical translation are discussed.
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