期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 22, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202001117
关键词
biomineralization; cancer therapy; drug delivery; inorganic materials; organic templates
资金
- National Natural Science Foundation of China [21876074, 21605071]
- Shandong Provincial Key Research and Development Program [GG201809250462]
- Taishan Scholars Program of Shandong Province [tsqn201812101]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2018R1D1A1B07045548]
- University of Suwon
- National Research Foundation of Korea [2018R1D1A1B07045548] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Biomineralization is a common process in organisms to produce hard biomaterials by combining inorganic ions with biomacromolecules. Multifunctional nanoplatforms are developed based on the mechanism of biomineralization in many biomedical applications. In the past few years, biomineralization-based nanoparticle drug delivery systems for the cancer treatment have gained a lot of research attention due to the advantages including simple preparation, good biocompatibility, degradability, easy modification, versatility, and targeting. In this review, the research trends of biomineralization-based nanoparticle drug delivery systems and their applications in cancer therapy are summarized. This work aims to promote future researches on cancer therapy based on biomineralization. Rational design of nanoparticle drug delivery systems can overcome the bottleneck in the clinical transformation of nanomaterials. At the same time, biomineralization has also provided new research ideas for cancer treatment, i.e., targeted therapy, which has significantly better performance.
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