期刊
ACS MACRO LETTERS
卷 9, 期 10, 页码 1471-1477出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.0c00619
关键词
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资金
- Sao Paulo Research Foundation (FAPESP/Brazil) [2017/05272-0, 2016/16221-4, 2017/03811-0, 2013/08617-7]
- National Council for Scientific and Technological Development (CNPq/Brazil) [301832/2017-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/03811-0, 16/16221-4, 17/05272-0] Funding Source: FAPESP
This work reports, for the encapsulation of L-asparaginase, an anticancer enzyme into hybrid PMPC25-PDPA(70)/PEO16-PBO22 asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze L-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on Lasparaginase.
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