期刊
MATERIALS
卷 13, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ma13204587
关键词
MXenes; chitosan; hyaluronate; nanocomposite hydrogel; antibacterial; porosity; computed tomography
类别
资金
- National Science Centre, within the framework of the research projects 'Preludium-17' [2019/33/N/ST5/02095]
- National Science Centre [UMO-2017/26/E/ST8/01073, UMO-2018/31/B/ST3/03758, UMO-2019/35/B/ST5/02538]
- BIOTECHMED-1 project - Warsaw University of Technology under the program Excellence Initiative: Research University (ID-UB)
A recent discovery of the unique biological properties of two-dimensional transition metal carbides (MXenes) resulted in intensive research on their application in various biotechnological areas, including polymeric nanocomposite systems. However, the true potential of MXene as an additive to bioactive natural porous composite structures has yet to be fully explored. Here, we report that the addition of 2D Ti3C2Tx MXene by reducing the porosity of the chitosan-hyaluronate matrix nanocomposite structures, stabilized by vitamin C, maintains their desired antibacterial properties. This was confirmed by micro computed tomography (micro-CT) visualization which enables insight into the porous structure of nanocomposites. It was also found that given large porosity of the nanocomposite a small amount of MXene (1-5 wt.%) was effective against gram-negative Escherichia coli, gram-positive Staphylococcus aureus, and Bacillus sp. bacteria in a hydrogel system. Such an approach unequivocally advances the future design approaches of modern wound healing dressing materials with the addition of MXenes.
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