期刊
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
卷 12, 期 4, 页码 638-651出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S204017442000080X
关键词
Donor conception; health survey; online; outcome; self-reported
资金
- Australian Government Research Training Program Scholarship
This study investigated the health outcomes of adult donor sperm-conceived people for the first time, finding that donor sperm-conceived adults reported higher frequencies of various health conditions compared to spontaneously conceived adults. These outcomes are consistent with data on birth defects from donor sperm treatment and the DOHaD theory linking early growth complications to chronic diseases in adulthood.
Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health outcomes of donor-conceived people. An online health survey was completed by 272 donor sperm-conceived adults and 877 spontaneously conceived adults from around the world. Donor and spontaneously conceived groups were matched for age, sex, height, smoking, alcohol consumption, exercise, own fertility and maternal smoking. Donor sperm-conceived adults had significantly higher reports of being diagnosed with type 1 diabetes (P = 0.031), thyroid disease (P = 0.031), acute bronchitis (P = 0.008), environmental allergies (P = 0.046), sleep apnoea (P = 0.037) and having ear tubes/grommets surgically implanted (P = 0.046). This is the first study to investigate the health outcomes of adult donor sperm-conceived people. Donor sperm-conceived adults self-reported elevated frequencies of various health conditions. The outcomes are consistent with birth defect data from donor sperm treatment and are consistent with the DOHaD linking perturbed early growth and chronic disease in adulthood.
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