期刊
ACS CATALYSIS
卷 10, 期 18, 页码 10672-10714出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c02957
关键词
enantioselective catalysis; transition metal catalysis; ligand; noncovalent interactions; density functional theory
资金
- Cambridge Trust
- Wolfson College Cambridge
- EPSRC
- GlaxoSmithKline
- Royal Society
- European Research Council (Horizon 2020) [757381]
- EPSRC [2110575] Funding Source: UKRI
- European Research Council (ERC) [757381] Funding Source: European Research Council (ERC)
Enantioselective transition metal catalysis is an area very much at the forefront of contemporary synthetic research. The development of processes that enable the efficient synthesis of enantiopure compounds is of unquestionable importance to chemists working within the many diverse fields of the central science. Traditional approaches to solving this challenge have typically relied on leveraging repulsive steric interactions between chiral ligands and substrates in order to raise the energy of one of the diastereomeric transition states over the other. By contrast, this Review examines an alternative tactic in which a set of attractive noncovalent interactions operating between transition metal ligands and substrates are used to control enantioselectivity. Examples where this creative approach has been successfully applied to render fundamental synthetic processes enantioselective are presented and discussed. In many of the cases examined, the ligand scaffold has been carefully designed to accommodate these attractive interactions, while in others, the importance of the critical interactions was only elucidated in subsequent computational and mechanistic studies. Through an exploration and discussion of recent reports encompassing a wide range of reaction classes, we hope to inspire synthetic chemists to continue to develop asymmetric transformations based on this powerful concept.
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