期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41467-020-19195-w
关键词
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资金
- National Natural Science Foundation of China [21602028]
- Recruitment Program of Global Experts
- Fuzhou University
Thiols are important precursors for the synthesis of a variety of pharmaceutically important sulfur-containing compounds. In view of the versatile reactivity of free thiols, here we report the development of a visible light-mediated direct decarboxylative thiolation reaction of alkyl redox-active esters to free thiols based on the abundant carboxylic acid feedstock. This transformation is applicable to various carboxylic acids, including primary, secondary, and tertiary acids as well as natural products and drugs, forging a general and facile access to free thiols with diverse structures. Moreover, the direct access to free thiols affords an advantage of rapid in situ diversification with high efficiency to other important thiol derivatives such as sulfide, disulfide, thiocyanide, thioselenide, etc. Thiols are important precursors for the synthesis of a variety of pharmaceutically important sulfur-containing compounds. Here, the authors report a visible light-mediated decarboxylative thiolation of alkyl redox-active esters to free thiols and the in situ product diversification of a number of thiol derivatives.
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