期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-17359-2
关键词
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资金
- Ontario Institute for Cancer Research by the Government of Ontario
- Discovery Frontiers: Advancing Big Data Science in Genomics Research program - Natural Sciences and Engineering Research Council (NSERC) of Canada
- Discovery Frontiers: Advancing Big Data Science in Genomics Research program - Canadian Institutes of Health Research (CIHR)
- Genome Canada
- Canada Foundation for Innovation (CFI)
- Terry Fox Research Institute New Investigator Award
- CIHR New Investigator Award
- NSERC
- Canadian Institutes of Health Research [SVB-145586]
- NIH/NCI [P30CA016042]
- National Cancer Institute Early Detection Research Network [1U01CA214194-01]
- MRC [MR/L008963/1, MC_U137961146, G1000729, MC_UU_12009/11, MC_UU_00016/11] Funding Source: UKRI
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
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