期刊
ONCOLOGY LETTERS
卷 20, 期 5, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.12116
关键词
oral squamous cell carcinoma; calcitonin gene-related peptide; cancer-associated pain; metabolic reprogramming; internalization; immune evasion
类别
资金
- National Natural Science Foundation of China [8187100500, 81702675]
- Science and Technology Commission of Shanghai Municipality [YDZX20173100004422]
Nerves have been widely demonstrated to exert major effects in tumor-associated microenvironments. Due to the characteristic innervation of the oral cavity and the fact that cancer-associated pain is a distinct feature of oral squamous cell carcinoma (OSCC), the sensory nerves may dominate in the OSCC-nerve microenvironment. As the most abundant neuropeptide in the trigeminal ganglion, the calcitonin gene-related peptide (CGRP) exerts a dual effect on cancer development and cancer-associated pain in various types of cancer. The present review explored the potential molecular mechanisms of the roles of CGRP in cancer development and cancer-associated pain, suggesting that CGRP may be a promising therapeutic target for OSCC.
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