期刊
JOURNAL OF FUNCTIONAL FOODS
卷 72, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104063
关键词
Obesity; Dietary fibre; Diabetes; Processed foods; Clinical trial; Maillard reaction
资金
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7 under REA [300815]
Melanoidins are Maillard reaction products similar to dietary fiber but their effect on food intake was under-investigated. A randomized, crossover study of 14 healthy subjects investigated whether melanoidins modulated energy intake and affected the postprandial dynamics of 21 gut-brain modulators of appetite including gastrointestinal peptides, endocannabinoids, N-acylethanolamines and neuropeptides. At breakfast the subjects consumed a bread enriched with either 3 g coffee melanoidins (CM), 3 g bread melanoidins (BM), or a conventional bread (CT). Energy intakes at lunch and throughout the day were measured, while appetite sensations and blood samples were collected before and 30, 60, 120, and 180 min after breakfast. Compared to CT, CM significantly reduced daily energy intake by 26%. CM lowered blood glucose peak, insulin, alpha-melanocyte stimulating hormone, orexin-A, beta-endorphin, and blunted the response of three N-acylethanolamines versus BM. Coffee melanoidins at breakfast reduces daily energy intake and modulates postprandial glycemia and other biomarkers.
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