期刊
JOURNAL OF FUNCTIONAL FOODS
卷 72, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104050
关键词
Pleurotus feruleus; Polysaccharides; Dendritic cell; Immunostimulatory activity; TLR4 signaling pathway
资金
- National Natural Science Foundation of China [U1803381]
- Doctoral Start-up Fund of Xinjiang University [BS180222]
Pleurotus feruleus is an edible and medicinal mushroom. We previously demonstrated that the crude and purified polysaccharides from cultivated P. feruleus (PFCP-C and PFPS-C) had the immunostimulatory activity. Here, the crude and purified polysaccharides of wild P. feruleus (PFCP-W and PFPS-W) were compared with PFCP-C and PFPS-C on the immunostimulatory activity. PFCP-W and PFCP-C showed similar activity on dendritic cell (DC) maturation in vitro, whereas the activity of PFCP-W was higher than that of PFCP-C in vivo. The monosaccharide compositions of PFPS-W and PFPS-C were different. PFPS-W was sulfated polysaccharides with crude surface. PFPS-W and PFPS-C promoted the activation of DCs and macrophages through TLR4 signaling pathway, whereas the activity of PFPS-W was higher than that of PFPS-C. The maturation and migration of DCs in vivo were significantly increased by PFPS-W and PFPS-C. Moreover, PFPS-W and PFPS-C significantly enhanced the antigen-specific cellular immune responses induced by DC-based vaccine.
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