Protective effects of Coreopsis tinctoria buds extract against cognitive impairment and brain aging induced by D-galactose

The study investigated the polyphenol of Coreopsis tinctoria buds extract (CTBE) and its protective effects on cognitive dysfunction and brain damage induced by d-galactose in mice. Three polyphenols and nine flavonoids were characterized by UPLC/Q-TOF-MS, with major components as flavanomarein (13.644 mg/g dry weight) and marein (13.387 mg/g dry weight). Results showed CTBE significantly improved the learning, memory, and cognitive abilities and brain index of aging mice. Besides, CTBE reduced the content of malondialdehyde while increased the activity of glutathione peroxidase and superoxide dismutase and the the total antioxidants in brain. CTBE reversed the abnormality of Ach level, AChE activity, and hippocampus changes in aging mice. Therefore, CTBE, as a novel nutraceutical, could attenuate the cognitive damage and improve parameters related to brain senescence, partly by reducing the oxidative stress and hippocampal damage.