期刊
JOURNAL OF FUNCTIONAL FOODS
卷 73, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104128
关键词
Lactobacillus plantarum; Geniposide; Genipin; CCl4; Liver injury; Antioxidant
资金
- Children's Research Institute of National Center for Schooling Development Programme [CSDP19FS01103]
- Chongqing University of Education [CSDP19FS01103]
- Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K201901601]
- Research Project of Chongqing University of Education, China [KY2015TBZC]
This study investigated Lactobacillus plantarum KFY02 (KFY02) and its ability to enhance the antioxidant capacity of the body by converting geniposide to genipin, thereby decreasing the liver damage induced by CCl4 in mice. The experimental results showed that geniposide is partially converted into genipin by KFY02. In liverinjured mice, KFY02 and geniposide could decrease the liver index, the AST, ALT, TG, and MDA serum levels, and the levels of cytokines IL-6, IL-12, TNF-alpha, and IFN-gamma while up-regulating SOD and GSH-Px levels. KFY02 and geniposide increased the mRNA and protein expression of Mn-SOD, Cu/Zn-SOD, CAT, GSH-Px, and I kappa B-alpha and decreased the mRNA and protein expression of COX-2, iNOS, and NF-kappa B in the liver tissue of liver-injured mice. In summary, the conversion of geniposide to genipin by L. plantarum KFY02 can effectively enhance the body's antioxidant capacity to prevent CCl4-induced liver damage in mice.
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