期刊
ONCOTARGETS AND THERAPY
卷 13, 期 -, 页码 9611-9622出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S266541
关键词
miRNAs; miR-424; tumor; regulation; carcinogenesis; cancer progression
资金
- Science and Technology Innovation Commission Foundation of Shenzhen [JCYJ20190808141013454, JCYJ20180305124827261]
microRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a posttranscriptional level. miRNA has gained increasing interest in recent years, both in research and clinical fields. miRNAs have been found to play an important role in various diseases, particularly cancer. Aberrant miR-424 expression is found in several tumors where they can function as either oncogenes or tumor-suppressor genes. Meanwhile, miR-424 is also affected by the reorganization of many other non-coding RNAs such as IncRNA and cirRNA. Several studies have found that miR-424 participates in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance, and plays an important role in the tumorigenesis and progression of tumors. This review will focus on the recent progress of research on miR-424 in tumors.
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