期刊
BMC MEDICAL GENOMICS
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12920-015-0078-0
关键词
Insulin resistance; Obesity; Co-expression network; Adipose tissue; Caucasian; African American; Transcript; Integrative genomics; Ethnic disparity
资金
- National Institutes of Health (NIH)/National Institute of Diabetes and Kidney Disease (NIDDK) [R01 DK039311]
- NIH/NIDDK [R01 DK090111]
- NIH/National Institute on Aging (NIA) [R01AG046170]
- NIH/National Cancer Institute (NCI) [R01CA163772]
- NIH/National Institute of Allergy and Infectious Diseases (NIAID) [U01AI111598-01]
- WFSM intramural faculty development fund
Background: African Americans (AA) have more pronounced insulin resistance and higher insulin secretion than European Americans (Caucasians or CA) when matched for age, gender, and body mass index (BMI). We hypothesize that physiological differences (including insulin sensitivity [S-I]) between CAs and AAs can be explained by co-regulated gene networks in tissues involved in glucose homeostasis. Methods: We performed integrative gene network analyses of transcriptomic data in subcutaneous adipose tissue of 99 CA and 37 AA subjects metabolically characterized as non-diabetic, with a range of S-I and BMI values. Results: Transcripts negatively correlated with S-I in only the CA or AA subjects were enriched for inflammatory response genes and integrin-signaling genes, respectively. A sub-network (module) with TYROBP as a hub enriched for genes involved in inflammatory response (corrected p = 1.7E-26) was negatively correlated with S-I (r = -0.426, p = 4.95E-04) in CA subjects. S-I was positively correlated with transcript modules enriched for mitochondrial metabolism in both groups. Several S-I-associated co-expressed modules were enriched for genes differentially expressed between groups. Two modules involved in immune response to viral infections and function of adherens junction, are significantly correlated with S-I only in CAs. Five modules involved in drug/intracellular transport and oxidoreductase activity, among other activities, are correlated with S-I only in AAs. Furthermore, we identified driver genes of these race-specific S-I-associated modules. Conclusions: S-I-associated transcriptional networks that were deranged predominantly in one ethnic group may explain the distinctive physiological features of glucose homeostasis among AA subjects.
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