期刊
CURRENT DRUG TARGETS
卷 17, 期 8, 页码 932-941出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450116666151102095825
关键词
AMPK; aging; metabolic dysfunction; stress oxidative; senescence
资金
- Fundacion Ramon Areces
- DGICYT (Departamento Gobernamental de Investigaciones Cientificas y Tecnologicas) [BFU2008-01552, BFU2011-27207]
- Junta de Andalucia
- MINECO [JCI-2011-08888]
Aging involves the progressive deterioration of physiological functions, diminishing the individual's capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.
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