期刊
VIRUSES-BASEL
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v12101089
关键词
gene regulation; transposable elements; endogenous retroviruses; epigenetic repression; Intracisternal A-type particle elements; position-effect variegation; KRAB-associated protein 1; X chromosome inactivation; genomic imprinting
类别
资金
- European Research Council [678350]
- Barts' Charity Lectureship award (MMBG1R)
- European Research Council (ERC) [678350] Funding Source: European Research Council (ERC)
The human genome has been under selective pressure to evolve in response to emerging pathogens and other environmental challenges. Genome evolution includes the acquisition of new genes or new isoforms of genes and changes to gene expression patterns. One source of genome innovation is from transposable elements (TEs), which carry their own promoters, enhancers and open reading frames and can act as 'controlling elements' for our own genes. TEs include LINE-1 elements, which can retrotranspose intracellularly and endogenous retroviruses (ERVs) that represent remnants of past retroviral germline infections. Although once pathogens, ERVs also represent an enticing source of incoming genetic material that the host can then repurpose. ERVs and other TEs have coevolved with host genes for millions of years, which has allowed them to become embedded within essential gene expression programmes. Intriguingly, these host genes are often subject to the same epigenetic control mechanisms that evolved to combat the TEs that now regulate them. Here, we illustrate the breadth of host gene regulation through TEs by focusing on examples of young (The New), ancient (The Old), and disease-causing (The Ugly) TE integrants.
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