期刊
CURRENT DRUG METABOLISM
卷 17, 期 5, 页码 412-429出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200217666151222155043
关键词
Aging; Alzheimer's disease; amyotrophic lateral sclerosis; glutamate excitotoxicity; Huntington's disease; kynurenine pathway; migraine; multiple sclerosis; neurodegeneration; neuroprotection; Parkinson's disease; picolinic acid; schizophrenia; Toxoplasma gondii
资金
- Hungarian Brain Research Program (NAP) [KTIA_13_NAP-A-III/9, KTIA_13_NAP-A-II/17]
- EURO-HEADPAIN (FP7-Health-Innovation) [602633]
- OTKA [K105077]
- MTA-SZTE Neuroscience Research Group of the Hungarian Academy of Sciences
- University of Szeged
- [TAMOP-4.2.6.3.1]
Introduction: The kynurenine pathway includes several neuroactive compounds, including kynurenic acid, picolinic acid, 3-hydroxykynurenine and quinolinic acid. The enzymatic cascade of the kynurenine pathway is tightly connected with the immune system, and may provide a link between the immune system and neurotransmission. Main Areas Covered: Alterations in this cascade are associated with neurodegenerative, neurocognitive, autoimmune and psychiatric disorders, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, migraine or schizophrenia. Highlights: This review highlights the alterations in this metabolic pathway in the physiological aging process and in different disorders. A survey is also presented of therapeutic possibilities of influencing this metabolic route, which can be achieved through the use of synthetic kynurenic acid analogues, enzyme inhibitors or even nanotechnology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据