期刊
CURRENT DIABETES REPORTS
卷 16, 期 8, 页码 -出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-016-0763-1
关键词
Metabolomics; Type 2 diabetes; Insulin resistance; Insulin secretion
资金
- American Diabetes Association
- NIH [T32 DK 007260]
- Harold Whitworth Pierce Charitable Trust Postdoctoral Fellowship
- Boston Nutrition and Obesity Research Center
- NIH
- Bristol-Myers Squibb
- Janssen
- Nuclea
- Medimmune
- Joslin DRC grant [P30 DK036836]
- [K99R00 HD064793]
Type 2 diabetes (T2D) is increasing worldwide, making identification of biomarkers for detection, staging, and effective prevention strategies an especially critical scientific and medical goal. Fortunately, advances in metabolomics techniques, together with improvements in bioinformatics and mathematical modeling approaches, have provided the scientific community with new tools to describe the T2D metabolome. The metabolomics signatures associated with T2D and obesity include increased levels of lactate, glycolytic intermediates, branched-chain and aromatic amino acids, and longchain fatty acids. Conversely, tricarboxylic acid cycle intermediates, betaine, and other metabolites decrease. Future studies will be required to fully integrate these and other findings into our understanding of diabetes pathophysiology and to identify biomarkers of disease risk, stage, and responsiveness to specific treatments.
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