期刊
CURRENT CANCER DRUG TARGETS
卷 16, 期 9, 页码 765-772出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009616666160216130755
关键词
Inflammation associated cancer; NF-kappa B; E2F1; therapeutic target
类别
资金
- Natural Science Foundation of Jiangsu Higher Education Institutions [13KJA330001]
- National Natural Science Foundation of China [91229125, 81520108027, 81521004]
- Foundation of the 973 Prophase Preparatory Project, Ministry Science and Technology [2014CB560705]
- Foundation of Priority Academic Program Development (PAPD)
- Collaborative Innovation Center for Cancer Personalized Medicine, Jiangsu Higher Education Institutions
- Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center
Inflammation is the fundamental protective response; however disordered immuno-response can cause chronic human disease, including cancer. Inflammatory cells and mediators are essential to the tumor microenvironment and dissection of this complex molecular and cellular milieu may elucidate a connection between cancer and inflammation and help to identify potential novel therapeutic targets. Thus, focusing on transcription factor NF-kappa B and E2F1 in inflammation-associated cancer is urgent. NF-kappa B activation is prevalent in carcinomas, mainly driven by inflammatory cytokines in the tumor microenvironment. E2F1 is also involved in regulating immune responses. Understanding the crosstalk between the two pathways may contribute to the development of novel anti-cancer drugs.
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