期刊
CURRENT CANCER DRUG TARGETS
卷 16, 期 6, 页码 489-508出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009616666151130214646
关键词
Tumor targeting; cancer; peptides; ligands
类别
资金
- National Science Foundation [DMR 1255281]
- Cohen Translational Fund
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1255281] Funding Source: National Science Foundation
Chemotherapeutic treatment of cancers is a challenging endeavor, hindered by poor selectivity towards tumorous tissues over healthy ones. Preferentially delivering a given drug to tumor sites necessitates the use of targeting elements, of which there are a wide range in development. In this Review, we highlight recent examples of peptide-based targeting ligands that have been exploited to selectively deliver a chemotherapeutic payload to specific tumor-associated sites such as the vasculature, lymphatics, or cell surface. The advantages and limitations of such approaches will be discussed with a view to potential future development. Additionally, we will also examine how peptide-based ligands can be used diagnostically in the detection and characterization of cancers through their incorporation into imaging agents.
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