期刊
CURRENT BIOLOGY
卷 26, 期 1, 页码 1-13出版社
CELL PRESS
DOI: 10.1016/j.cub.2015.11.020
关键词
-
资金
- CNRS
- INSERM
- Institut Curie
- NIH grants [GM077569, NS088503]
- National Eye Institute [R01 EY015625]
- NIAMS [R01 AR048155]
- Fondation pour la Recherche Medicale (FRM) [DEQ20140329491]
- CelTisPhyBio Labex [ANR-10-LBX-0038]
- IDEX PSL [ANR-10-IDEX-0001-02 PSL]
- [F32 AR062476]
Recycling endosomes consist of a tubular network that emerges from vacuolar sorting endosomes and diverts cargoes toward the cell surface, the Golgi, or lysosome-related organelles. How recycling tubules are formed remains unknown. We show that recycling endosome biogenesis requires the protein complex BLOC-1. Mutations in BLOC-1 subunits underlie an inherited disorder characterized by albinism, the Hermansky-Pudlak Syndrome, and are associated with schizophrenia risk. We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment of recycling tubules. These components cooperate to extend, stabilize and form tubular endosomal carriers that function in cargo recycling and in the biogenesis of pigment granules in melanocytic cells. By shaping recycling endosomal tubules, our data reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the pathophysiology of neurological and pigmentary disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据