期刊
CURRENT BIOLOGY
卷 26, 期 11, 页码 1427-1434出版社
CELL PRESS
DOI: 10.1016/j.cub.2016.03.076
关键词
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资金
- Fundacao para a Ciencia e Tecnologia (FCT) through POPH-QREN funds from the European Social Fund
- Portuguese MCTES (FCT) [IF/00283/2014/CP1256/CT0012, IF/00033/2014, SFRH/BPD/84141/2012]
- Biodiversity, Genetics, and Evolution (BIODIV) PhD program at CIBIO/InBIO [PD/BD/108131/2015]
- University of Porto
- project Genomics and Evolutionary Biology - North Portugal Regional Operational Programme (ON. 2-O Novo Norte) under the National Strategic Reference Framework (NSRF)
- project Genomics Applied to Genetic Resources'' - North Portugal Regional Operational Programme (ON. 2-O Novo Norte) under the National Strategic Reference Framework (NSRF)
- European Regional Development Fund (ERDF)
- EU [286431]
- NSF-IOS [1243207]
- Office of the Vice President for Research at Auburn University
- Human Frontier Science Program grant
- NIH [R01EY024958, R01EY026672, EY013360]
- National Science Foundation [1202776]
- McDonnell Center for Cellular and Molecular Neurobiology at Washington University
- Cabildo de La Palma, Consejeria de Medio Ambiente, Transportes y Seguridad y Emergencias
- Fundação para a Ciência e a Tecnologia [PD/BD/108131/2015] Funding Source: FCT
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1243207] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1202776] Funding Source: National Science Foundation
The yellow and red feather pigmentation of many bird species [1] plays pivotal roles in social signaling and mate choice [2, 3]. To produce red pigments, birds ingest yellow carotenoids and endogenously convert them into red ketocarotenoids via an oxidation reaction catalyzed by a previously unknown ketolase [4-6]. We investigated the genetic basis for red coloration in birds using whole-genome sequencing of red siskins (Spinus cucullata), common canaries (Serinus canaria), and red factor canaries, which are the hybrid product of crossing red siskins with common canaries [7]. We identified two genomic regions introgressed from red siskins into red factor canaries that are required for red coloration. One of these regions contains a gene encoding a cytochrome P450 enzyme, CYP2J19. Transcriptome analysis demonstrates that CYP2J19 is significantly upregulated in the skin and liver of red factor canaries, strongly implicating CYP2J19 as the ketolase that mediates red coloration in birds. Interestingly, a second introgressed region required for red feathers resides within the epidermal differentiation complex, a cluster of genes involved in development of the integument. Lastly, we present evidence that CYP2J19 is involved in ketocarotenoid formation in the retina. The discovery of the carotenoid ketolase has important implications for understanding sensory function and signaling mediated by carotenoid pigmentation.
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