期刊
CURRENT BIOLOGY
卷 26, 期 18, 页码 R859-R864出版社
CELL PRESS
DOI: 10.1016/j.cub.2016.08.004
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资金
- FIC NIH HHS [U19 TW009872] Funding Source: Medline
- NIAID NIH HHS [U19 AI109673] Funding Source: Medline
- NIGMS NIH HHS [R01 GM086258] Funding Source: Medline
The small molecules produced by environmental bacteria have been mainstays of both chemical and biological research for decades, and some have led to important therapeutic interventions. These small molecules have been shaped by natural selection as they evolved to fulfill Changing functional roles in their native environments. This minireview describes some recent systematic studies providing illustrative examples that involve the acquisition and alteration of genetic information for molecular innovation by bacteria in well-defined environments. Two different bacterial genera are featured, Pseudonocardia and Salinispora, and, although the small-molecule repertoires of both have benefited from horizontal gene transfer, Pseudonocardia spp. have relied on plasmid-based tactics while Salinispora spp. have relied on chromosomally integrated genomic islands.
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