期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 41, 期 10, 页码 715-729出版社
CELL PRESS
DOI: 10.1016/j.tips.2020.08.002
关键词
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资金
- Research Grant Council, Hong Kong [GRF17301918, GRF17300319]
- Seed Funding for Strategic Interdisciplinary Research Scheme, The University of Hong Kong
RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe and effective delivery system. Studies investigating RNA therapeutics in pulmonary diseases have rapidly expanded and drug administration by inhalation allows the direct delivery of RNA therapeutics to the target site of action while minimizing systemic exposure. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. We also discuss the major knowledge gaps that require thorough investigation and provide insights that will help advance this exciting field towards the bedside.
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