期刊
TRENDS IN MICROBIOLOGY
卷 29, 期 5, 页码 428-440出版社
CELL PRESS
DOI: 10.1016/j.tim.2020.10.001
关键词
-
资金
- National Institutes of Health (NIH) [GM49640]
Ancient microbes developed biochemical mechanisms and core metabolic pathways on an anoxic Earth, but had to evolve defensive tactics to combat the damaging effects of oxygen and reactive oxygen species (ROS) later on. Recent studies have identified enzymes targeted by ROS and revealed various protective strategies to enhance scavenging systems, shedding light on a more comprehensive and surprising understanding of oxygen toxicity.
Ancient microbes invented biochemical mechanisms and assembled core metabolic pathways on an anoxic Earth. Molecular oxygen appeared far later, forcing microbes to devise layers of defensive tactics that fend off the destructive actions of both reactive oxygen species (ROS) and oxygen itself. Recent work has pinpointed the enzymes that ROS attack, plus an array of clever protective strategies that abet the well known scavenging systems. Oxygen also directly damages the low-potential metal centers and radical-based mechanisms that optimize anaerobic metabolism; therefore, committed anaerobes have evolved customized tactics that defend these various enzymes from occasional oxygen exposure. Thus a more comprehensive, detailed, and surprising view of oxygen toxicity is coming into view.
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