Gene Regulation and Cellular Metabolism: An Essential Partnership

It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the primary fuel driving gene expression. However, metabolic conditions are highly variable since nutrient uptake is not a uniform process. Thus, cells must continually calibrate gene expression to their changing metabolite and energy budgets. This review discusses recent advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene regulation as cells navigate their growth, proliferation, and differentiation. Particular focus is given to these mechanisms in the context of organismal development.

Automated summary

Cell metabolism is closely connected to gene expression regulation, providing precursor molecules and ATP for gene expression. However, metabolic conditions are highly variable, requiring cells to continually calibrate gene expression to adapt to changing metabolite and energy budgets. Recent advances in understanding the molecular and biophysical mechanisms connecting metabolism and gene regulation, particularly in the context of organismal development, are discussed in this review.