期刊
TRENDS IN CELL BIOLOGY
卷 30, 期 10, 页码 805-817出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2020.08.004
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资金
- Japan Society for the Promotion of Science (JSPS) [16K15226]
- JSPS [26291043, 18H02440, 18K06234, 16K18544]
- MEXT/JSPS [17H05627]
- National Institutes of Natural Sciences (NINS)
- Inamori Foundation
- Takeda Science Foundation
- Japan Spina Bifida and Hydrocephalus Research Foundation
Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ structure and function, and additional players including junctional adhesion molecules (JAMs), membrane lipids, phase separation of the zonula occludens (ZO) family of scaffolding proteins, and mechanical force have been shown to play important roles in TJ structure and function. In this review, we discuss how these new findings have the potential to transform our understanding of TJ structure and function, and how the intricate network of TJ proteins and membrane lipids dynamically interact to drive TJ assembly.
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