Nanozymes based on metal-organic frameworks: Construction and prospects

Nanozymes, the nanomaterials with catalytic function similar to natural enzymes, are well-known for their distinct merits such as low cost and high stability. Among them, metal-organic frameworks (MOFs) based nanozymes have attracted more attention. It is not only because of its large surface area, adjustable pore structure and good biocompatibility, but also due to its inorganic-organic hybrid structure which can be designed to own different mimic enzyme activities. In addition, MOFs with the above structural characteristics can be used to construct multi-enzyme cascade system to better simulate natural enzymes. In this review, MOFs-based single and multienzyme systems have been introduced. Besides, we summarized some strategies to enhance their catalytic activity. Moreover, the applications in analytical chemistry, environmental treatment and diseases treatment have been reviewed. Finally, the current challenges and future perspective on the development of MOFs-based nanozymes are discussed. (C) 2020 Elsevier B.V. All rights reserved.