期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 133, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2020.116080
关键词
Metal-organic frameworks; Nanozymes; Multienzyme systems; Catalytic activity; Applications
资金
- Natural Science Foundation Projects of China [81950410634, QNJ20200010003]
- Independent Innovation Fund Project of Agricultural Science and Technology of Jiangsu Province in 2017 [CX (17) 1003]
- Chinese College Students Innovation Project for the R&D of Novel Drugs [201910316195]
Nanozymes, the nanomaterials with catalytic function similar to natural enzymes, are well-known for their distinct merits such as low cost and high stability. Among them, metal-organic frameworks (MOFs) based nanozymes have attracted more attention. It is not only because of its large surface area, adjustable pore structure and good biocompatibility, but also due to its inorganic-organic hybrid structure which can be designed to own different mimic enzyme activities. In addition, MOFs with the above structural characteristics can be used to construct multi-enzyme cascade system to better simulate natural enzymes. In this review, MOFs-based single and multienzyme systems have been introduced. Besides, we summarized some strategies to enhance their catalytic activity. Moreover, the applications in analytical chemistry, environmental treatment and diseases treatment have been reviewed. Finally, the current challenges and future perspective on the development of MOFs-based nanozymes are discussed. (C) 2020 Elsevier B.V. All rights reserved.
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