期刊
THORAX
卷 75, 期 12, 页码 1089-1094出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2020-215414
关键词
viral infection; infection control; clinical epidemiology; respiratory infection
资金
- University of Birmingham
- University Hospitals Birmingham NHS Foundation Trust
- NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham
- International AIDS Vaccine Initiative
- Bill and Melinda Gates Foundation through the Collaboration for AIDS Vaccine Discovery [OPP1084519, OPP1115782]
- Scripps Consortium for HIV Vaccine Development (CHAVD) [AI144462]
- University of Southampton Coronavirus Response Fund
- Cancer Research UK Advanced Clinician Scientist award [C31641/A23923]
- CRUK Centre Birmingham [C17422/A25154]
- Birmingham Experimental Cancer Medicine Centre [C11497/A25127]
- MRC [MR/M009157/1, MC_PC_17183] Funding Source: UKRI
Objective To determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers. Design A cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020. Setting University Hospitals Birmingham NHS Foundation Trust (UHBFT), UK. Participants 545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded. Intervention Participants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked. Main outcome measure Proportion of participants demonstrating infection and positive SARS-CoV-2 serology. Results The point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, chi(2)=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02). Conclusions and relevance We identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.
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