期刊
TETRAHEDRON LETTERS
卷 61, 期 41, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.152398
关键词
Cleavable linker; Monomethyl auristatin E; MMAE; Phosphoramidate; Payload click-ready
资金
- National Institutes of Health [CA223121]
In this work, we developed a novel click-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at physiological pHs while rapidly releasing its payload at acidic pH. The linker can also be tailored to release payloads of diverse functional groups, broadening its applications. (C) 2020 Elsevier Ltd. All rights reserved.
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