期刊
TETRAHEDRON LETTERS
卷 61, 期 41, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.152384
关键词
3-Hydroxy-4H-pyran-4-ones; alpha-Ketoaldehydes; Methylene active nitriles; 2-Aminofurans; Multicomponent reaction
A novel efficient one-pot method for the preparation of 2-aminofurans was developed based on multi-component reaction of 3-hydroxy-4H-pyran-4-ones, alpha-ketoaldehydes and methylene active nitriles. A distinctive feature of the proposed approach is the formation of 2-aminofurans in contrast to related literature methods leading to 2-aminopyrans. The advantages of this synthesis include high yields, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of the 2-aminofuran derivatives was determined by X-ray diffraction. (C) 2020 Elsevier Ltd. All rights reserved.
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