期刊
SYNTHESIS-STUTTGART
卷 53, 期 1, 页码 30-50出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1705918
关键词
asymmetric hydrogenation; asymmetric transfer hydrogenation; dynamic kinetic resolution; chiral alcohols; chiral amines; enantioselectivity; diastereoselectivity
资金
- CNRS (Centre National de la Recherche Scientifique)
- MENESR (Ministere de l'Education Nationale, de l'Enseignement Superieur et de la Recherche)
- MENESR
This short review focuses on the development of efficient, atom-economical, and sustainable methods for the production of chiral alcohols and amines, particularly through homogeneous asymmetric catalysis. It discusses asymmetric hydrogenation and transfer hydrogenation, as well as dynamic kinetic resolution as key approaches to constructing up to three stereogenic centers.
Based on the ever-increasing demand for enantiomerically pure compounds, the development of efficient, atom-economical, and sustainable methods to produce chiral alcohols and amines is a major concern. Homogeneous asymmetric catalysis with transition-metal complexes including asymmetric hydrogenation (AH) and transfer hydrogenation (ATH) of ketones and imines through dynamic kinetic resolution (DKR) allowing the construction of up to three stereogenic centers is the main focus of the present short review, emphasizing the development of new catalytic systems combined to new classes of substrates and their applications as well.
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