期刊
SURVEY OF OPHTHALMOLOGY
卷 66, 期 3, 页码 423-440出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2020.09.002
关键词
aging; age-related macular degeneration; antioxidant therapy; oxidative stress
资金
- Research to Prevent Blindness
Age-related macular degeneration is the leading cause of irreversible visual loss among older adults in developed countries, with oxidative stress playing a key role in its pathobiology. Targeted antioxidant therapy may help prevent or improve specific stages of the disease.
Age-related macular degeneration, the leading cause of irreversible visual loss among older adults in developed countries, is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in age-related macular degeneration that results from aging and the accu-mulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in age-related macular degeneration pathobiology. We also offer targeted therapy that may define how antioxidant therapy can either prevent or improve specific stages of age-related macular degeneration. (c) 2020 Elsevier Inc. All rights reserved.
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