期刊
SURGERY TODAY
卷 51, 期 5, 页码 686-694出版社
SPRINGER
DOI: 10.1007/s00595-020-02121-4
关键词
Staging laparoscopy; Pancreatic cancer; Resectability
类别
资金
- JSPS KAKENHI [19K18107]
- Grants-in-Aid for Scientific Research [19K18107] Funding Source: KAKEN
This study evaluated the safety and usefulness of staging laparoscopy in detecting distant metastases in patients with pancreatic cancer. The results showed that staging laparoscopy can be safely performed and is useful for diagnosing radiologically negative metastases.
Purpose Staging laparoscopy is considered useful for determining treatment plans for advanced pancreatic cancer. However, the indications for staging laparoscopy are not clear. This study aimed to evaluate the safety of staging laparoscopy and its usefulness for detecting distant metastases in patients with pancreatic cancer. Methods A total of 146 patients with pancreatic cancer who underwent staging laparoscopy between 2013 and 2019 were analyzed. Staging laparoscopy was performed in all pancreatic cancer patients in whom surgery was considered possible. Results In this cohort, 42 patients (29%) were diagnosed with malignant cells on peritoneal lavage cytology, 9 (6%) had peritoneal dissemination, and 11 (8%) had liver metastases. A total of 48 (33%) had radiologically negative metastases. On a multivariate analysis, body and tail cancer [odds ratio (OR) 5.00, 95% confidence interval (CI) 2.15-11.6,p < 0.001], high CA19-9 level [OR 4.04, 95% CI 1.74-9.38,p = 0.001], and a resectability status of unresectable (OR 2.31, 95% CI 1.03-5.20,p = 0.04) were independent risk factors for radiologically negative metastases. Conclusions Staging laparoscopy can be safely performed and is useful for the diagnosis of radiologically negative metastases. Staging laparoscopy should be routinely performed for the accurate diagnosis of pancreatic cancer patients before pancreatectomy and/or local treatment, such as radiotherapy.
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