期刊
SURGERY FOR OBESITY AND RELATED DISEASES
卷 17, 期 2, 页码 329-337出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.soard.2020.09.030
关键词
Bariatric surgery; Sleeve gastrectomy; Gastroesophageal reflux; Manometry; Obesity; MII-pH
类别
资金
- Johnson& Johnson Medical Pty Ltd
The study found that laparoscopic sleeve gastrectomy (SG) significantly increased intragastric pressures, without affecting esophageal motility or acid exposure. For patients without preexisting reflux, there were significant increases in acid exposure time, long reflux episodes, weakly acidic reflux episodes, and DeMeester score after SG.
Background: Laparoscopic sleeve gastrectomy (SG) is increasingly popular but concern regarding its effect on gastroesophageal reflux disease remain. The current literature is conflicting, and there have been little objective data. Objectives: To objectively and more accurately assess the impact of SGon esophago-gastric physiology. Setting: Centre of Excellence in Metabolic and Bariatric Surgery, Private Hospital, Australia. Methods: Prospective cohort study of 31 patients undergoing SG with high-resolution impedance manometry (HRM), 24-hour multichannel intraluminal impedance combined with pH testing (MII-pH), and Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) questionnaire 1 month before and 6 months after SG. Results: There were 31 patients that underwent SG, 20 with synchronous hiatal repair and fixation, and 6 that were excluded. HRM demonstrated significantly increased intragastric pressures(15.5-29.6 mm Hg) and failed swallows (3.1-7.5%) but no other change in esophageal motility. MII-pH did not demonstrate significant changes in acid exposure time (8.5%-7.5%) or number of reflux episodes, although the numbers of long reflux episodes (2.3-4.7) and weak acid reflux episodes were significantly increased (15.4-55.2). DeMeester and GSAS scores were not significantly changed. There was no significant difference in patients with preexisting reflux. However, for patients without preexisting reflux, acid exposure time increased significantly (1.3%-6.7%), as did DeMeester scores (5.8-24.5) and the numbers of long reflux episodes (.1-4.4) and weakly acidic episodes (22.1-89.2). Conclusion: SG was associated with increased intragastric pressures, without changes in esophageal motility or acid exposure. For patients without preexisting reflux, there were increases in acid exposure time, long reflux episodes, weakly acidic reflux episodes, and DeMeester score. Crown Copyright (C) 2020 Published by Elsevier Inc. on behalf of American Society for Bariatric Surgery. All rights reserved.
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